This week, CNN.com is running a series about autism. If you are not familiar with autism, here's a little primer about this condition.
Autism is a disorder of brain development that usually appears before the age of 3 that results in developmental delays causing problems with communication, social development and interaction. Many children with autism are of average to high intelligence, but some children are more profoundly affected than others, which results in their being unable to function independently. Autism has no cure, and persists throughout the person's life.
Some autism advocates contend that autism is caused by vaccinations, but many experts have dismissed that claim as fallacious and that vaccinations are not the cause of autism. However, a recent legal ruling siding with a Georgia family who claims their daughter developed autism only after receiving the MMR vaccine (a widely administered vaccine to children of school age, and required by Texas state law for students in public school) has given autism advocates fuel for this argument.
However, this story at CNN.com seems to point to a genetic link to autism. The women in the story were all single women who wanted to have children, so they turned to a sperm bank to obtain donor sperm for artificial insemination. Women who were inseminated with "Donor X"'s sperm bore children who later went on to develop autism.
Researchers have identified regions of the genome that perhaps contribute to the development of autism but that have not actually been identified as actual causative agents of the condition.
How does the discovery of genomic regions help to provide evidence supporting an organic cause for autism rather than an environmental cause? More importantly, how does the Georgia case illustrate the effect of environmental factors on gene expression? Genes are not autonomous entities that control their own expression on their own terms.
Other questions that can and should be raised by this issue are: should sperm donors be screened for potentially deadly/disabling genes in their genomes? Is something like this practical? What other problems arise from a reproductive medical system that allows almost any man to donate sperm for artificial insemination, regardless of genomic content?
Posted by scienceguru on April 7, 2008
Tags bioethics, brains!, discuss, genetics


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